This Policy Forum issue analyses both progress made by and challenges facing the Chemical Weapons Convention (CWC) and Biological and Toxin Weapons Convention (BTWC). It does so in order to explore under what conditions and to what extent these two conventions might help build a zone in the Middle East free of weapons of mass destruction (WMD) and their delivery vehicles (DVs). Finally, the issue presents some options for the future and a major long-term initiative towards this ambitious goal.